Current Issue : October - December Volume : 2012 Issue Number : 4 Articles : 5 Articles
Background: Cosmeceuticals are cosmetic-pharmaceutical hybrids intended to enhance health and beauty of the\r\nskin. Nanocosmeceuticals use nano-sized system for the delivery of active ingredients to the targeted cells for\r\nbetter penetration. In this work, nanoemulsion from palm oil esters was developed as a delivery system to produce\r\nnanocosmeceuticals. The stability of the resulting formulation was tested using various methods. In addition, the\r\neffect of components i.e. Vitamin E and Pluronic F-68 on the formulation was also studied.\r\nResults: Both vitamin E and Pluronic F-68 were found to co-emulsify and co-stabilized the formulations. The best\r\nformulation was found to be the one having the composition of 10% Palm Oil Esters (POEs), 10% vitamin E, 24%\r\nTween 80, 2.4% Pluronic F-68 and 53.6% deionised water. Those compositions are considered to be the best as a\r\nnanocosmeceutical product due to the small particle size (94.21 nm), low occurrence of Ostwald ripening and\r\nstable at different storing temperatures (5, 25 and 45�°C) for four weeks.\r\nConclusions: Palm oil esters-in-water nanoemulsions loaded with vitamin E was successfully formulated and has\r\nthe potential for the use as nanocosmeceuticals...
Chemically stable ester derivatives of vitamins A, C and E have become a focus\r\nof interest for their role in the satisfactory results in skin aging treatments. Accordingly,\r\nthe aim of this study was to evaluate the physical and chemical stability of a cosmetic\r\nformulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl\r\nacetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer\r\nwas used to determine rheological behavior of formulations containing the vitamins.\r\nChemical stability was determined by HPLC on a Shimadzu system with UV detection.\r\nResults showed that formulations had pseudoplastic behavior and that vitamins did not\r\nalter their apparent viscosity and thixotropy. In the chemical stability studies,\r\nfirst-order reaction equations were used for determinations of the shelf-life of vitamins\r\nderivatives considering a remaining concentration of 85%. Combined vitamins in a single\r\nformulation had a slightly lower degradation rate as compared to different preparations\r\ncontaining only one of the vitamins. Considering that many cosmetic formulations contain\r\nvitamin combinations it is suggested that the present study may contribute to the\r\ndevelopment of more stable formulations containing liposoluble vitamins....
Cosmeceuticals represent one of the most promising, yet challenging treatment options available to physicians.\r\nThey are the fastest growth segment in the skin-care market, and a number of topical cosmeceutical treatments for conditions\r\nsuch as photoaging, hyperpigmentation, and wrinkles have come into widespread use. This comprehensive review\r\nattempts to examine the current literature of the more commonly encountered cosmeceutical agents in order to determine\r\ntheir utility in treating various dermatologic conditions, as well as their potential use in the area of wound healing. Each\r\nsection, dealing with a different agent, provides a brief chemical background, a review of the published research studies,\r\nand nally concludes with a prediction about its potential role in skin regeneration. Although further research needs to be\r\nconducted, adjuvant cosmeceutical therapy may help in prevention of skin cancer, photoaging, and the rejuvenation of skin\r\nduring wound healing....
This paper describes recent data on the effects of various skin formulations containing hydroxyacids (HAs) and related products on\r\nsun-exposed skin. The most frequently used classes of these products, such as a- and �Ÿ-hydroxyacids, polyhydroxy acids, and bionic\r\nacids, are reviewed, and their application in cosmetic formulations is described. Special emphasis is devoted to the safety evaluation\r\nof these formulations, particularly on the effects of their prolonged use on sun-exposed skin.We also discuss the important contribution\r\nof cosmetic vehicles in these types of studies. Data on the effects of HAs on melanogenesis and tanning are also included.\r\nUp-to-date methods and techniques used in those explorations, as well as selected future developments in the cosmetic area, are\r\npresented....
Aloe barbadensis (Aloe Vera) is a well-known plant belonging to family liliaceae with rich source of anthraquinone glycosides and polysaccharides. Aloe vera is used extensively in the cosmetic and healthcare industries. However estimation of active constituents of aloe in any of the marketed product is not reported yet because of lack of availability of suitable phyto-marker. Hence, in the present investigation attempts have been made to identify phyto-marker from the aloe juice and exploration of identified marker as tool for estimation of aloe in marketed cosmeceutical products. From the published research report it has been observed that activity of aloe vera is due to the presence of several phytonutrients and polysaccharides like acemannan. Acemannan, specifically in aloe vera has been identified but not explored extensively as a marker for detection of aloe vera gel in cosmeceutical formulations. Further, the estimation technique based on spectroscopy i.e. nuclear magnetic resonance (NMR) / fourier transform infrared (FT-IR) and chromatographic i.e. gel chromatography / size exclusion high performance liquid chromatography (SE-HPLC) has been reported for estimation of acemannan, but these techniques require sophisticated instruments and are expensive as well as laborious which make them unsuitable for routine quality control checks for acemannan in the formulations. In view of the reported constraints, the present work focuses on a development and validation very simple and sensitive colorimetric assay method for estimation of acemannan in an aloe vera containing products with extended calibration curve for improved detection. In present exploration, estimation sensitivity of acemannan was enhanced by derivatization using congo red dye which make stable congo red-aloe polysaccharide chromogenic complex. Three formulations namely Lab scale developed cream, Marketed Formulation 1 and Marketed Formulation 2 were studied with acemannan as a phytomarker for aloe vera. The developed spectrophotometric method accurately measured acemannan in the sample, which was implicated by stable red color in the presence of Congo red. Overall proposed spectrophotometric technique for determination of aloe polysaccharide in different formulations was found to be robust, accurate, sensitive and precise for routine quality analysis of aloe vera in cosmeceuticals formulation....
Loading....